Assay Detail
Binding
CHEMBL747408
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In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.36 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279356 | — | — | 1 | 7.85 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.77 |
| CHEMBL23721 | — | — | 1 | 7.32 |
| CHEMBL23335 | — | — | 1 | 7.12 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.94 |
| CHEMBL276975 | — | — | 1 | 6.85 |
| CHEMBL434772 | — | — | 1 | 6.77 |
| CHEMBL23563 | — | — | 1 | 6.62 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.49 |
| CHEMBL429230 | — | — | 1 | 6.03 |
| CHEMBL22926 | — | — | 1 | 5.47 |
| CHEMBL278352 | — | — | 1 | 5.34 |
| CHEMBL23222 | — | — | 1 | 5.30 |
| CHEMBL23962 | — | — | 1 | 5.19 |
| CHEMBL22925 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279356 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL23721 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL23335 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL276975 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL434772 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL23563 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL9967 | PIRENZEPINE | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL429230 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL22926 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL278352 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL23222 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL23962 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL22925 | — | IC50 | = | 40000.0 | nM | 4.40 |