Assay Detail
Binding
CHEMBL747409
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In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenates
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.10 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.67 |
| CHEMBL434772 | — | — | 1 | 5.80 |
| CHEMBL279356 | — | — | 1 | 5.75 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 5.48 |
| CHEMBL23721 | — | — | 1 | 5.35 |
| CHEMBL23335 | — | — | 1 | 5.35 |
| CHEMBL276975 | — | — | 1 | 5.29 |
| CHEMBL23563 | — | — | 1 | 4.80 |
| CHEMBL23222 | — | — | 1 | 4.70 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 4.59 |
| CHEMBL429230 | — | — | 1 | 4.54 |
| CHEMBL22926 | — | — | 1 | 4.52 |
| CHEMBL278352 | — | — | 1 | 4.28 |
| CHEMBL23962 | — | — | 1 | 4.22 |
| CHEMBL22925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9967 | PIRENZEPINE | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL434772 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL279356 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL23721 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL23335 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL276975 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL23563 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL23222 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL429230 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL22926 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL278352 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL23962 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL22925 | — | IC50 | = | 165000.0 | nM | - |