Assay Detail
Binding
CHEMBL747410
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Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.75 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | 7.92 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 7.89 |
| CHEMBL23118 | — | — | 1 | 7.52 |
| CHEMBL23172 | — | — | 1 | 6.37 |
| CHEMBL282490 | — | — | 1 | 5.64 |
| CHEMBL23901 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL667 | ACETYLCHOLINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL23118 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL23172 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL282490 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL23901 | — | IC50 | = | 6700.0 | nM | 5.17 |