Assay Detail
Binding
CHEMBL747415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.11 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351934 | — | — | 1 | 8.20 |
| CHEMBL350949 | — | — | 1 | 8.11 |
| CHEMBL159273 | — | — | 1 | 7.96 |
| CHEMBL355824 | — | — | 1 | 7.92 |
| CHEMBL346030 | — | — | 1 | 7.91 |
| CHEMBL349025 | — | — | 1 | 7.85 |
| CHEMBL161007 | — | — | 1 | 7.55 |
| CHEMBL349066 | — | — | 1 | 7.43 |
| CHEMBL422538 | — | — | 1 | 7.36 |
| CHEMBL159628 | — | — | 1 | 7.23 |
| CHEMBL161670 | — | — | 1 | 7.22 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 7.11 |
| CHEMBL159841 | — | — | 1 | 7.11 |
| CHEMBL161088 | — | — | 1 | 7.06 |
| CHEMBL161364 | — | — | 1 | 6.99 |
| CHEMBL161748 | — | — | 1 | 6.97 |
| CHEMBL159708 | — | — | 1 | 6.84 |
| CHEMBL162134 | — | — | 1 | 6.84 |
| CHEMBL159651 | — | — | 1 | 6.74 |
| CHEMBL159935 | — | — | 1 | 6.74 |
| CHEMBL159839 | — | — | 1 | 6.72 |
| CHEMBL262517 | — | — | 1 | 6.54 |
| CHEMBL422710 | — | — | 1 | 6.17 |
| CHEMBL161189 | — | — | 1 | 6.16 |
| CHEMBL161419 | — | — | 1 | 6.02 |
| CHEMBL349844 | — | — | 1 | 6.02 |
| CHEMBL159311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351934 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL350949 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL159273 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL355824 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL346030 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL349025 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL161007 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL349066 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL422538 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL159628 | — | IC50 | = | 58.5 | nM | 7.23 |
| CHEMBL161670 | — | IC50 | = | 59.9 | nM | 7.22 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL159841 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL161088 | — | IC50 | = | 86.2 | nM | 7.06 |
| CHEMBL161364 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL161748 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL159708 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL162134 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL159651 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL159935 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL159839 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL262517 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL422710 | — | IC50 | = | 681.0 | nM | 6.17 |
| CHEMBL161189 | — | IC50 | = | 685.0 | nM | 6.16 |
| CHEMBL161419 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL349844 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL159311 | — | IC50 | > | 850.0 | nM | - |