Assay Detail
Binding
CHEMBL747479
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Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.43 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 8.15 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.77 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.42 |
| CHEMBL12587 | MUSCARINE | — | 1 | 7.14 |
| CHEMBL310558 | — | — | 1 | 6.72 |
| CHEMBL315428 | — | — | 1 | 6.51 |
| CHEMBL314493 | — | — | 1 | 6.04 |
| CHEMBL440138 | — | — | 1 | 5.92 |
| CHEMBL85190 | — | — | 1 | 5.89 |
| CHEMBL313738 | — | — | 1 | 5.80 |
| CHEMBL84113 | — | — | 1 | 5.77 |
| CHEMBL294273 | — | — | 1 | 5.36 |
| CHEMBL82754 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL14 | CARBACHOL | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL12587 | MUSCARINE | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL310558 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL315428 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL314493 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL440138 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL85190 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL313738 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL84113 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL294273 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL82754 | — | Ki | = | 9000.0 | nM | 5.05 |