Assay Detail
Binding
CHEMBL747481
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Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.53 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 8.59 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.70 |
| CHEMBL12587 | MUSCARINE | — | 1 | 7.60 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 7.40 |
| CHEMBL85190 | — | — | 1 | 6.58 |
| CHEMBL84113 | — | — | 1 | 6.52 |
| CHEMBL315428 | — | — | 1 | 6.44 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.18 |
| CHEMBL313738 | — | — | 1 | 6.14 |
| CHEMBL314493 | — | — | 1 | 6.09 |
| CHEMBL440138 | — | — | 1 | 5.62 |
| CHEMBL294273 | — | — | 1 | 5.57 |
| CHEMBL310558 | — | — | 1 | 5.51 |
| CHEMBL82754 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL14 | CARBACHOL | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL12587 | MUSCARINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL7303 | ARECOLINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL85190 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL84113 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL315428 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL313738 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL314493 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL440138 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL294273 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL310558 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL82754 | — | Ki | = | 3600.0 | nM | 5.44 |