Assay Detail
Binding
CHEMBL747511
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Activity against rat cortical and hippocampal membrane N-methyl-D-aspartate glutamate receptor 1/2A/2B/2C/2D using [3H]CPP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.47 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 4.92 |
| CHEMBL417544 | — | — | 1 | 4.60 |
| CHEMBL278097 | — | — | 1 | 4.47 |
| CHEMBL50160 | — | — | 1 | 4.23 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | 4.12 |
| CHEMBL295718 | — | — | 1 | - |
| CHEMBL53744 | — | — | 1 | - |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | -1.0 | 1 | - |
| CHEMBL31344 | — | — | 1 | - |
| CHEMBL278390 | INDOLE-2-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL301556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL417544 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL278097 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL50160 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL299155 | TRANSTORINE | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL295718 | — | IC50 | = | 283000.0 | nM | - |
| CHEMBL53744 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | IC50 | = | 162000.0 | nM | - |
| CHEMBL31344 | — | IC50 | = | 358000.0 | nM | - |
| CHEMBL278390 | INDOLE-2-CARBOXYLIC ACID | IC50 | = | 4200000.0 | nM | - |
| CHEMBL301556 | — | IC50 | > | 1000000.0 | nM | - |