Assay Detail
Binding
CHEMBL747587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.55 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 9.02 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 8.28 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.22 |
| CHEMBL12587 | MUSCARINE | — | 1 | 8.08 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.28 |
| CHEMBL294273 | — | — | 1 | 7.04 |
| CHEMBL84113 | — | — | 1 | 6.36 |
| CHEMBL85190 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL7303 | ARECOLINE | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL12587 | MUSCARINE | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL14 | CARBACHOL | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL294273 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL84113 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL85190 | — | Ki | = | 790.0 | nM | 6.10 |