Assay Detail
Binding
CHEMBL747588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor of rat heart membranes.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.75 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.48 |
| CHEMBL64000 | — | — | 1 | 6.40 |
| CHEMBL84113 | — | — | 1 | 5.85 |
| CHEMBL85190 | — | — | 1 | 5.85 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.72 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.54 |
| CHEMBL12587 | MUSCARINE | — | 1 | 5.36 |
| CHEMBL294273 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL64000 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL84113 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL85190 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL7303 | ARECOLINE | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL14 | CARBACHOL | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL12587 | MUSCARINE | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL294273 | — | Ki | = | 17000.0 | nM | 4.77 |