Assay Detail
Binding
CHEMBL747712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DAMGO from mouse brain homogenate Mu opioid receptor
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.00 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2051964 | — | — | 1 | 7.81 |
| CHEMBL101516 | — | — | 1 | 7.38 |
| CHEMBL100911 | — | — | 1 | 7.24 |
| CHEMBL327745 | — | — | 1 | 7.22 |
| CHEMBL316863 | — | — | 1 | 7.05 |
| CHEMBL108076 | — | — | 1 | 7.03 |
| CHEMBL100729 | — | — | 3 | 6.89 |
| CHEMBL327956 | — | — | 1 | 6.86 |
| CHEMBL322181 | — | — | 1 | 6.85 |
| CHEMBL101623 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2051964 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL101516 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL100911 | — | Ki | = | 57.9 | nM | 7.24 |
| CHEMBL327745 | — | Ki | = | 59.6 | nM | 7.22 |
| CHEMBL316863 | — | Ki | = | 89.4 | nM | 7.05 |
| CHEMBL108076 | — | Ki | = | 93.2 | nM | 7.03 |
| CHEMBL100729 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL327956 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL322181 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL100729 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL101623 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL100729 | — | Ki | > | 5000.0 | nM | - |