Assay Detail
Functional
CHEMBL747754
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Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6000 nM CTAP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.65 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | — | 1 | 6.17 |
| CHEMBL440765 | U-69593 | — | 1 | 5.67 |
| CHEMBL102497 | — | — | 1 | 5.44 |
| CHEMBL115730 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | Kd | = | 673.0 | nM | 6.17 |
| CHEMBL440765 | U-69593 | Kd | = | 2142.0 | nM | 5.67 |
| CHEMBL102497 | — | Kd | = | 3604.0 | nM | 5.44 |
| CHEMBL115730 | — | Kd | = | 4667.0 | nM | 5.33 |