Assay Detail
Functional
CHEMBL747756
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Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes in unblocked condition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.02 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | — | 1 | 6.50 |
| CHEMBL31421 | — | — | 1 | 6.24 |
| CHEMBL440765 | U-69593 | — | 1 | 6.17 |
| CHEMBL102497 | — | — | 1 | 5.75 |
| CHEMBL115730 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | Kd | = | 317.0 | nM | 6.50 |
| CHEMBL31421 | — | Kd | = | 577.0 | nM | 6.24 |
| CHEMBL440765 | U-69593 | Kd | = | 684.0 | nM | 6.17 |
| CHEMBL102497 | — | Kd | = | 1782.0 | nM | 5.75 |
| CHEMBL115730 | — | Kd | = | 3500.0 | nM | 5.46 |