Assay Detail
Binding
CHEMBL747763
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigs
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.67 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.42 |
| CHEMBL300689 | — | — | 2 | 7.27 |
| CHEMBL431156 | — | — | 1 | 6.99 |
| CHEMBL50098 | — | — | 1 | 6.91 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | 6.35 |
| CHEMBL297281 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL300689 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL431156 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL50098 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL607 | MEPERIDINE | Ki | = | 451.0 | nM | 6.35 |
| CHEMBL300689 | — | Ki | = | 1015.0 | nM | 5.99 |
| CHEMBL297281 | — | Ki | = | 1654.0 | nM | 5.78 |