Assay Detail
Binding
CHEMBL747774
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Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovarian |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification and characterization of m4 selective muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.66 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277642 | HIMBACINE | — | 1 | 7.76 |
| CHEMBL1092 | TRIHEXYPHENIDYL HYDROCHLORIDE | 4.0 | 1 | 7.73 |
| CHEMBL294726 | — | — | 1 | 5.94 |
| CHEMBL61700 | — | — | 1 | 5.78 |
| CHEMBL61412 | — | — | 1 | 5.72 |
| CHEMBL62247 | — | — | 1 | 5.59 |
| CHEMBL62251 | — | — | 1 | 5.58 |
| CHEMBL301041 | — | — | 1 | 5.57 |
| CHEMBL300987 | — | — | 1 | 5.52 |
| CHEMBL59898 | — | — | 1 | 5.46 |
| CHEMBL60142 | — | — | 1 | 5.34 |
| CHEMBL61774 | — | — | 1 | 5.33 |
| CHEMBL61494 | — | — | 1 | 5.11 |
| CHEMBL58228 | — | — | 1 | 5.03 |
| CHEMBL303758 | — | — | 1 | 5.02 |
| CHEMBL59939 | — | — | 1 | 4.88 |
| CHEMBL59347 | — | — | 1 | 4.83 |
| CHEMBL304036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277642 | HIMBACINE | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL1092 | TRIHEXYPHENIDYL HYDROCHLORIDE | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL294726 | — | IC50 | = | 1151.5 | nM | 5.94 |
| CHEMBL61700 | — | IC50 | = | 1646.0 | nM | 5.78 |
| CHEMBL61412 | — | IC50 | = | 1905.1 | nM | 5.72 |
| CHEMBL62247 | — | IC50 | = | 2565.0 | nM | 5.59 |
| CHEMBL62251 | — | IC50 | = | 2643.0 | nM | 5.58 |
| CHEMBL301041 | — | IC50 | = | 2680.7 | nM | 5.57 |
| CHEMBL300987 | — | IC50 | = | 3002.9 | nM | 5.52 |
| CHEMBL59898 | — | IC50 | = | 3440.7 | nM | 5.46 |
| CHEMBL60142 | — | IC50 | = | 4563.5 | nM | 5.34 |
| CHEMBL61774 | — | IC50 | = | 4662.4 | nM | 5.33 |
| CHEMBL61494 | — | IC50 | = | 7703.7 | nM | 5.11 |
| CHEMBL58228 | — | IC50 | = | 9341.4 | nM | 5.03 |
| CHEMBL303758 | — | IC50 | = | 9524.7 | nM | 5.02 |
| CHEMBL59939 | — | IC50 | = | 13138.0 | nM | 4.88 |
| CHEMBL59347 | — | IC50 | = | 14677.7 | nM | 4.83 |
| CHEMBL304036 | — | IC50 | < | 1000.0 | nM | - |