Assay Detail
Binding
CHEMBL747816
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Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M3 subtype
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.65 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286008 | — | — | 1 | 8.77 |
| CHEMBL284137 | — | — | 1 | 8.40 |
| CHEMBL285440 | — | — | 1 | 7.51 |
| CHEMBL285898 | — | — | 1 | 6.80 |
| CHEMBL24369 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286008 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL284137 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL285440 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL285898 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL24369 | — | Ki | = | 178.0 | nM | 6.75 |