Assay Detail
Binding
CHEMBL747822
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Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.25 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 6.17 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.24 |
| CHEMBL294273 | — | — | 1 | 4.82 |
| CHEMBL64788 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL7303 | ARECOLINE | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL294273 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL64788 | — | Ki | = | 18000.0 | nM | 4.75 |