Assay Detail
Binding
CHEMBL747824
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Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M3 expressed in CHO cell membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.36 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 6.17 |
| CHEMBL84113 | — | — | 1 | 5.89 |
| CHEMBL313738 | — | — | 1 | 5.52 |
| CHEMBL85190 | — | — | 1 | 5.50 |
| CHEMBL314493 | — | — | 1 | 5.17 |
| CHEMBL440138 | — | — | 1 | 5.13 |
| CHEMBL82754 | — | — | 1 | 5.12 |
| CHEMBL310558 | — | — | 1 | 4.94 |
| CHEMBL294273 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL84113 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL313738 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL85190 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL314493 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL440138 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL82754 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL310558 | — | Ki | = | 11400.0 | nM | 4.94 |
| CHEMBL294273 | — | Ki | = | 15000.0 | nM | 4.82 |