Assay Detail
Binding
CHEMBL747826
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Binding affinity against Muscarinic acetylcholine receptor M3
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.41 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114068 | — | — | 1 | 9.89 |
| CHEMBL71124 | — | — | 1 | 9.80 |
| CHEMBL2115128 | — | — | 1 | 9.42 |
| CHEMBL71147 | — | — | 1 | 9.32 |
| CHEMBL307810 | — | — | 1 | 9.01 |
| CHEMBL71971 | — | — | 1 | 8.17 |
| CHEMBL71531 | — | — | 1 | 7.86 |
| CHEMBL2115127 | — | — | 1 | 7.70 |
| CHEMBL2114067 | — | — | 1 | 7.56 |
| CHEMBL2111540 | — | — | 1 | 7.53 |
| CHEMBL2114064 | — | — | 1 | 7.43 |
| CHEMBL2115126 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114068 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL71124 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL2115128 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL71147 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL307810 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL71971 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL71531 | — | Ki | = | 13.76 | nM | 7.86 |
| CHEMBL2115127 | — | Ki | = | 20.1 | nM | 7.70 |
| CHEMBL2114067 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL2111540 | — | Ki | = | 29.4 | nM | 7.53 |
| CHEMBL2114064 | — | Ki | = | 37.04 | nM | 7.43 |
| CHEMBL2115126 | — | Ki | = | 58.8 | nM | 7.23 |