Assay Detail
Binding
CHEMBL747849
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Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.86 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553214 | — | — | 1 | 6.51 |
| CHEMBL540395 | — | — | 1 | 6.10 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 5.92 |
| CHEMBL554629 | — | — | 1 | 5.48 |
| CHEMBL541927 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553214 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL540395 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL554629 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL541927 | — | IC50 | = | 5400.0 | nM | 5.27 |