Assay Detail
Binding
CHEMBL747859
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Inhibitory concentration required for in vitro binding affinity to cholinergic central Nicotinic acetylcholine receptor on rat brain cortex by using [3H]MCC
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.44 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58416 | — | — | 1 | 8.47 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.40 |
| CHEMBL291780 | — | — | 1 | 7.64 |
| CHEMBL291442 | — | — | 1 | 7.58 |
| CHEMBL274525 | ABT-418 | — | 1 | 7.28 |
| CHEMBL144540 | — | — | 1 | 7.07 |
| CHEMBL60656 | — | — | 1 | 6.77 |
| CHEMBL293142 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58416 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3 | NICOTINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL291780 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL291442 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL274525 | ABT-418 | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL144540 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL60656 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL293142 | — | IC50 | = | 500.0 | nM | 6.30 |