Assay Detail
Binding
CHEMBL747872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]CTOP binding to rat brain homogenate mu-opioid receptor
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.60 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289006 | — | — | 1 | 8.29 |
| CHEMBL284621 | — | — | 1 | 5.92 |
| CHEMBL317956 | DELTORPHIN C | — | 2 | 5.78 |
| CHEMBL32202 | — | — | 1 | 5.72 |
| CHEMBL2372209 | — | — | 1 | 5.72 |
| CHEMBL2372213 | — | — | 1 | 5.48 |
| CHEMBL286629 | — | — | 1 | 5.42 |
| CHEMBL2372208 | — | — | 1 | 5.31 |
| CHEMBL2372214 | — | — | 1 | 4.99 |
| CHEMBL288317 | — | — | 1 | 4.58 |
| CHEMBL2372212 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289006 | — | IC50 | = | 5.15 | nM | 8.29 |
| CHEMBL284621 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL32202 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2372209 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL2372213 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL286629 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL2372208 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2372214 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL288317 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL2372212 | — | IC50 | = | 54600.0 | nM | 4.26 |