Assay Detail
Binding
CHEMBL747873
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Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.52 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372328 | — | — | 1 | 7.08 |
| CHEMBL2372327 | — | — | 1 | 6.96 |
| CHEMBL2372329 | — | — | 1 | 6.75 |
| CHEMBL339320 | — | — | 1 | 6.55 |
| CHEMBL2372314 | — | — | 1 | 6.28 |
| CHEMBL31421 | — | — | 1 | 6.21 |
| CHEMBL2372310 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372328 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2372327 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2372329 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL339320 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2372314 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL31421 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2372310 | — | IC50 | = | 1600.0 | nM | 5.80 |