Assay Detail
Binding
CHEMBL747874
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Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.12 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25230 | — | — | 1 | 8.01 |
| CHEMBL303855 | — | — | 1 | 7.33 |
| CHEMBL69052 | — | — | 1 | 6.78 |
| CHEMBL70111 | — | — | 1 | 6.37 |
| CHEMBL67195 | — | — | 1 | 5.63 |
| CHEMBL611159 | — | — | 1 | 5.61 |
| CHEMBL13470 | SNC-80 | — | 2 | 5.24 |
| CHEMBL67378 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25230 | — | IC50 | = | 9.71 | nM | 8.01 |
| CHEMBL303855 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL69052 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL70111 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL67195 | — | IC50 | = | 2322.0 | nM | 5.63 |
| CHEMBL611159 | — | IC50 | = | 2467.0 | nM | 5.61 |
| CHEMBL13470 | SNC-80 | IC50 | = | 5712.0 | nM | 5.24 |
| CHEMBL67378 | — | IC50 | = | 9138.0 | nM | 5.04 |
| CHEMBL13470 | SNC-80 | IC50 | = | 9366.0 | nM | 5.03 |