Assay Detail
Binding
CHEMBL747997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-nisoxatine from norepinephrine transporter of rat brain membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.45 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 6.07 |
| CHEMBL112825 | — | — | 1 | 5.89 |
| CHEMBL2112513 | — | — | 1 | 5.86 |
| CHEMBL113144 | — | — | 1 | 5.86 |
| CHEMBL2112516 | — | — | 1 | 5.50 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.48 |
| CHEMBL2112509 | — | — | 1 | 5.43 |
| CHEMBL2112514 | — | — | 1 | 5.25 |
| CHEMBL2112511 | — | — | 1 | 5.21 |
| CHEMBL113195 | — | — | 1 | 5.19 |
| CHEMBL2112512 | — | — | 1 | 5.18 |
| CHEMBL2112515 | — | — | 1 | 5.16 |
| CHEMBL2112508 | — | — | 1 | 5.16 |
| CHEMBL2112510 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 844.0 | nM | 6.07 |
| CHEMBL112825 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2112513 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL113144 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL2112516 | — | Ki | = | 3170.0 | nM | 5.50 |
| CHEMBL370805 | COCAINE | Ki | = | 3302.0 | nM | 5.48 |
| CHEMBL2112509 | — | Ki | = | 3720.0 | nM | 5.43 |
| CHEMBL2112514 | — | Ki | = | 5690.0 | nM | 5.25 |
| CHEMBL2112511 | — | Ki | = | 6206.0 | nM | 5.21 |
| CHEMBL113195 | — | Ki | = | 6390.0 | nM | 5.19 |
| CHEMBL2112512 | — | Ki | = | 6610.0 | nM | 5.18 |
| CHEMBL2112515 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL2112508 | — | Ki | = | 6910.0 | nM | 5.16 |
| CHEMBL2112510 | — | Ki | = | 10200.0 | nM | 4.99 |