Assay Detail
Binding
CHEMBL747998
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Displacement of from norepinephrine transporter of frozen rat caudate membranes
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.10 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | 2.0 | 1 | 8.22 |
| CHEMBL543372 | — | — | 1 | 8.15 |
| CHEMBL89142 | — | — | 1 | 8.05 |
| CHEMBL300019 | — | — | 2 | 7.82 |
| CHEMBL301514 | — | — | 1 | 7.62 |
| CHEMBL89752 | — | — | 1 | 6.36 |
| CHEMBL554565 | — | — | 1 | 6.09 |
| CHEMBL316341 | — | — | 2 | 6.00 |
| CHEMBL315697 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL543372 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL89142 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL300019 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL301514 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL300019 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL89752 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL554565 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL316341 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL315697 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL316341 | — | Ki | > | 4700.0 | nM | - |