Assay Detail
Binding
CHEMBL748000
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Evaluated for the Competitive inhibition of uptake of norepinephrine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.78 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130653 | — | — | 1 | 8.30 |
| CHEMBL132149 | — | — | 1 | 8.10 |
| CHEMBL131384 | — | — | 1 | 7.96 |
| CHEMBL130521 | — | — | 1 | 7.89 |
| CHEMBL28225 | — | — | 1 | 7.58 |
| CHEMBL132012 | — | — | 1 | 7.34 |
| CHEMBL337702 | OXIDOPAMINE | 2.0 | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130653 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL132149 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL131384 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL130521 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL28225 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL132012 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL337702 | OXIDOPAMINE | Ki | = | 51.0 | nM | 7.29 |