Assay Detail
Binding
CHEMBL748002
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In vitro binding affinity of compound for Norepinephrine (NE) transporter with [3H]- nisoxatine as radioligand in corpus striatum tissue from rat forebrain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Corpus striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Phthalimidoalkyl derivatives of 2-carbomethoxy-3-(4-iodophenyl)tropane (-CIT): Brain monoamine transporter affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.18 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14391 | — | — | 1 | 8.55 |
| CHEMBL432029 | — | — | 1 | 7.22 |
| CHEMBL2112550 | — | — | 1 | 7.13 |
| CHEMBL423692 | — | — | 1 | 7.12 |
| CHEMBL114837 | — | — | 1 | 6.72 |
| CHEMBL114547 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14391 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL432029 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL2112550 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL423692 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL114837 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL114547 | — | Ki | = | 441.0 | nM | 6.36 |