Assay Detail
Binding
CHEMBL748003
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In vitro binding affinity towards Norepinephrine transporter rat cerebral cortical homogenates by [3H]nisoxetine displacement.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.64 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14391 | — | — | 1 | 8.55 |
| CHEMBL149801 | — | — | 1 | 7.54 |
| CHEMBL318755 | — | — | 1 | 7.20 |
| CHEMBL2112550 | — | — | 1 | 7.13 |
| CHEMBL358006 | — | — | 1 | 7.03 |
| CHEMBL345553 | — | — | 1 | 7.02 |
| CHEMBL153361 | — | — | 1 | 6.96 |
| CHEMBL356652 | — | — | 1 | 6.79 |
| CHEMBL150084 | — | — | 1 | 6.70 |
| CHEMBL357300 | — | — | 1 | 6.66 |
| CHEMBL2112890 | — | — | 1 | 6.28 |
| CHEMBL2079586 | — | — | 1 | 6.20 |
| CHEMBL153602 | — | — | 1 | 5.30 |
| CHEMBL153200 | — | — | 1 | 5.30 |
| CHEMBL345760 | — | — | 1 | 5.00 |
| CHEMBL356166 | — | — | 1 | - |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | - |
| CHEMBL370805 | COCAINE | 4.0 | 1 | - |
| CHEMBL346872 | — | — | 1 | - |
| CHEMBL153121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14391 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL149801 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL318755 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL2112550 | — | Ki | = | 73.7 | nM | 7.13 |
| CHEMBL358006 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL345553 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL153361 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL356652 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL150084 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL357300 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL2112890 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL2079586 | — | Ki | = | 635.0 | nM | 6.20 |
| CHEMBL153602 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL153200 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL345760 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL356166 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL281594 | VANOXERINE | Ki | > | 20000.0 | nM | - |
| CHEMBL370805 | COCAINE | Ki | > | 30000.0 | nM | - |
| CHEMBL346872 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL153121 | — | Ki | > | 10000.0 | nM | - |