Assay Detail
Binding
CHEMBL748007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for norepinephrine transporter (NET) labeled with [3H]nisoxetine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.18 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | 2.0 | 1 | 8.24 |
| CHEMBL543688 | — | — | 1 | 7.82 |
| CHEMBL542500 | — | — | 1 | 7.57 |
| CHEMBL543449 | — | — | 1 | 7.12 |
| CHEMBL541602 | — | — | 1 | 7.03 |
| CHEMBL541605 | — | — | 1 | 6.99 |
| CHEMBL545559 | — | — | 1 | 6.91 |
| CHEMBL554033 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL543688 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL542500 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL543449 | — | Ki | = | 76.5 | nM | 7.12 |
| CHEMBL541602 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL541605 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL545559 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL554033 | — | Ki | = | 1686.0 | nM | 5.77 |