Assay Detail
Binding
CHEMBL748009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound for depolarization induced by 5 uM NMDA in mouse cortical wedge preparation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.30 | 4.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432748 | — | — | 1 | 4.44 |
| CHEMBL307267 | — | — | 1 | 4.38 |
| CHEMBL310286 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432748 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL307267 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL310286 | — | Ki | = | 84000.0 | nM | 4.08 |