Assay Detail
Binding
CHEMBL748018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace radioligand [3H](-)-cytisine from Nicotinic acetylcholine receptor in rat brain membrane.
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of pyridine-modified analogues of 3-(2-aminoethoxy)pyridine as novel nicotinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 64 | 7.84 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419932 | — | — | 1 | 10.12 |
| CHEMBL333162 | — | — | 1 | 10.11 |
| CHEMBL112127 | — | — | 1 | 10.09 |
| CHEMBL325352 | — | — | 1 | 10.00 |
| CHEMBL112467 | — | — | 1 | 9.74 |
| CHEMBL112254 | — | — | 1 | 9.43 |
| CHEMBL113391 | — | — | 1 | 9.28 |
| CHEMBL323696 | — | — | 1 | 9.24 |
| CHEMBL115098 | — | — | 1 | 9.01 |
| CHEMBL441650 | — | — | 1 | 8.82 |
| CHEMBL323697 | — | — | 1 | 8.82 |
| CHEMBL111935 | — | — | 1 | 8.82 |
| CHEMBL113130 | — | — | 1 | 8.59 |
| CHEMBL112316 | — | — | 1 | 8.44 |
| CHEMBL432643 | — | — | 1 | 8.35 |
| CHEMBL112961 | — | — | 1 | 8.34 |
| CHEMBL109271 | — | — | 1 | 8.28 |
| CHEMBL324939 | — | — | 1 | 8.26 |
| CHEMBL114505 | — | — | 1 | 8.26 |
| CHEMBL114881 | — | — | 1 | 8.23 |
| CHEMBL109767 | — | — | 1 | 8.18 |
| CHEMBL332720 | — | — | 1 | 8.15 |
| CHEMBL113431 | — | — | 1 | 8.14 |
| CHEMBL113240 | — | — | 1 | 8.06 |
| CHEMBL320325 | — | — | 1 | 8.02 |
| CHEMBL110202 | — | — | 1 | 8.00 |
| CHEMBL111905 | — | — | 1 | 7.96 |
| CHEMBL113260 | — | — | 1 | 7.96 |
| CHEMBL324020 | — | — | 1 | 7.92 |
| CHEMBL112989 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419932 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL333162 | — | Ki | = | 0.077 | nM | 10.11 |
| CHEMBL112127 | — | Ki | = | 0.081 | nM | 10.09 |
| CHEMBL325352 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL112467 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL112254 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL113391 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL323696 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL115098 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL441650 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL323697 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL111935 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL113130 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL112316 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL432643 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL112961 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL109271 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL324939 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL114505 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL114881 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL109767 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL332720 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL113431 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL113240 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL320325 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL110202 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL113260 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL111905 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL324020 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL112989 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL113295 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL113488 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL111821 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL326536 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL112221 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL113101 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL420496 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL112677 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL61616 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL325212 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL112471 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL112083 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL325898 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL112749 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL326918 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL115886 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL113319 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL112744 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL113076 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL326051 | — | Ki | = | 79.0 | nM | 7.10 |