Assay Detail
Binding
CHEMBL748035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.18 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159952 | — | — | 1 | 9.03 |
| CHEMBL1159940 | — | — | 1 | 8.92 |
| CHEMBL1159933 | — | — | 1 | 8.85 |
| CHEMBL1159942 | — | — | 1 | 8.70 |
| CHEMBL1159925 | — | — | 1 | 8.66 |
| CHEMBL1159930 | — | — | 1 | 8.64 |
| CHEMBL1159927 | — | — | 1 | 8.54 |
| CHEMBL1159936 | — | — | 1 | 8.48 |
| CHEMBL1159939 | — | — | 1 | 8.31 |
| CHEMBL1159953 | — | — | 1 | 7.93 |
| CHEMBL1159932 | — | — | 1 | 7.81 |
| CHEMBL1159950 | — | — | 1 | 7.49 |
| CHEMBL1159919 | — | — | 1 | 7.37 |
| CHEMBL1159941 | — | — | 1 | 7.29 |
| CHEMBL1159924 | — | — | 1 | 7.16 |
| CHEMBL1159921 | — | — | 1 | 7.10 |
| CHEMBL1159954 | — | — | 1 | 6.98 |
| CHEMBL1159928 | — | — | 1 | 6.96 |
| CHEMBL1159931 | — | — | 1 | 6.85 |
| CHEMBL1159947 | — | — | 1 | 6.84 |
| CHEMBL1159934 | — | — | 1 | 6.82 |
| CHEMBL1159955 | — | — | 1 | 6.80 |
| CHEMBL1159937 | — | — | 1 | 6.80 |
| CHEMBL1159961 | — | — | 1 | 6.75 |
| CHEMBL1159926 | — | — | 1 | 6.73 |
| CHEMBL1159916 | — | — | 1 | 6.72 |
| CHEMBL1159949 | — | — | 1 | 6.72 |
| CHEMBL1159920 | — | — | 1 | 6.72 |
| CHEMBL1159956 | — | — | 1 | 6.64 |
| CHEMBL1159935 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159952 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL1159940 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1159933 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1159942 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1159925 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1159930 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1159927 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1159936 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL1159939 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL1159953 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL1159932 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL1159950 | — | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL1159919 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1159941 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1159924 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL1159921 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1159954 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL1159928 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1159931 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1159947 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL1159934 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1159955 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL1159937 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL1159961 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL1159926 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL1159916 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1159949 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1159920 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1159956 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1159935 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL1159959 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL1159938 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL1159944 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL1159923 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1159922 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1159945 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1159917 | — | Ki | = | 10000.0 | nM | 5.00 |