Assay Detail
Binding
CHEMBL748042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of rat kidney neutral endopeptidase (NEP) by fluorometric assay using Dansyl-Gly-Phe-Arg as substrate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Mercaptoacyl dipeptides as dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Preliminary structure-activity studies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.75 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50625 | — | — | 1 | 8.80 |
| CHEMBL51988 | — | — | 1 | 8.70 |
| CHEMBL50312 | — | — | 1 | 8.66 |
| CHEMBL50582 | — | — | 1 | 8.59 |
| CHEMBL49920 | — | — | 1 | 8.41 |
| CHEMBL51715 | — | — | 1 | 8.24 |
| CHEMBL50914 | — | — | 1 | 8.21 |
| CHEMBL299181 | — | — | 1 | 8.18 |
| CHEMBL422403 | — | — | 1 | 8.18 |
| CHEMBL51428 | — | — | 1 | 8.18 |
| CHEMBL51466 | — | — | 1 | 8.03 |
| CHEMBL50915 | — | — | 1 | 8.00 |
| CHEMBL50954 | — | — | 1 | 7.60 |
| CHEMBL50595 | — | — | 1 | 7.50 |
| CHEMBL295936 | — | — | 1 | 7.40 |
| CHEMBL50203 | — | — | 1 | 7.35 |
| CHEMBL51301 | — | — | 1 | 7.06 |
| CHEMBL440856 | — | — | 1 | 6.85 |
| CHEMBL300880 | — | — | 1 | 6.80 |
| CHEMBL50414 | — | — | 1 | 6.74 |
| CHEMBL51625 | — | — | 1 | 6.54 |
| CHEMBL287896 | — | — | 1 | 6.40 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50625 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL51988 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL50312 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL50582 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL49920 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL51715 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL50914 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL299181 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL422403 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL51428 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL51466 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL50915 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL50954 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL50595 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL295936 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL50203 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL51301 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL440856 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL300880 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL50414 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL51625 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL287896 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 830000.0 | nM | - |