Assay Detail
Binding
CHEMBL748048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for displacement of radioligand [3H]-Naloxone from opiate receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.89 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441636 | — | — | 1 | 7.52 |
| CHEMBL328583 | — | — | 1 | 7.26 |
| CHEMBL328019 | — | — | 1 | 6.82 |
| CHEMBL92960 | — | — | 1 | 6.70 |
| CHEMBL92779 | — | — | 1 | 6.40 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | 6.30 |
| CHEMBL92124 | — | — | 1 | 6.05 |
| CHEMBL89961 | — | — | 1 | 5.40 |
| CHEMBL285244 | — | — | 1 | 5.30 |
| CHEMBL96626 | — | — | 1 | 5.10 |
| CHEMBL92787 | — | — | 1 | 4.70 |
| CHEMBL440699 | — | — | 1 | 4.70 |
| CHEMBL329911 | — | — | 1 | 4.30 |
| CHEMBL93306 | — | — | 1 | - |
| CHEMBL90632 | — | — | 1 | - |
| CHEMBL92403 | — | — | 1 | - |
| CHEMBL92303 | — | — | 1 | - |
| CHEMBL93296 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441636 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL328583 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL328019 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL92960 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL92779 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL607 | MEPERIDINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL92124 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL89961 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL285244 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL96626 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL92787 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL440699 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL329911 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL93306 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL90632 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL92403 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL92303 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL93296 | — | IC50 | = | 200000.0 | nM | - |