Assay Detail
Binding
CHEMBL748051
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Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-S
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | A9L |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL3733) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.35 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12378 | — | — | 1 | 8.98 |
| CHEMBL277014 | — | — | 1 | 8.60 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 8.26 |
| CHEMBL538467 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12378 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL277014 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL7303 | ARECOLINE | Ki | = | 5.45 | nM | 8.26 |
| CHEMBL538467 | — | Ki | = | 26.8 | nM | 7.57 |