Assay Detail
Binding
CHEMBL748066
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Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]TCP as the radioligand.
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Potent quinoxaline-spaced phosphono alpha-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.79 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114829 | — | — | 1 | 5.25 |
| CHEMBL116797 | — | — | 1 | 5.07 |
| CHEMBL42990 | — | — | 1 | 4.93 |
| CHEMBL115671 | — | — | 1 | 4.86 |
| CHEMBL114315 | — | — | 1 | 4.79 |
| CHEMBL324706 | — | — | 2 | 4.68 |
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 4.65 |
| CHEMBL22304 | — | — | 1 | 4.35 |
| CHEMBL274440 | AP-7 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114829 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL116797 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL42990 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL115671 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL114315 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL324706 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL39664 | SELFOTEL | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL324706 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL22304 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL274440 | AP-7 | IC50 | = | 302000.0 | nM | - |