Assay Detail
Functional
CHEMBL748098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity for suppression of membrane current response elicited by fixed concentration of glycine and glutamate in Xenopus oocyte expressing N-methyl-D-aspartate glutamate receptor 1/2B
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2b (CHEMBL2096666) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.28 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31741 | — | — | 1 | 7.75 |
| CHEMBL139982 | — | — | 1 | 7.62 |
| CHEMBL337851 | — | — | 1 | 7.50 |
| CHEMBL138208 | — | — | 1 | 7.41 |
| CHEMBL138159 | — | — | 1 | 6.81 |
| CHEMBL139009 | — | — | 1 | 6.70 |
| CHEMBL337346 | — | — | 1 | 6.47 |
| CHEMBL136791 | — | — | 1 | 5.62 |
| CHEMBL344145 | — | — | 1 | 4.62 |
| CHEMBL137509 | — | — | 1 | 4.42 |
| CHEMBL276907 | — | — | 1 | 4.20 |
| CHEMBL136501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31741 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL139982 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL337851 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL138208 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL138159 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL139009 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL337346 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL136791 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL344145 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL137509 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL276907 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL136501 | — | IC50 | > | 100000.0 | nM | - |