Assay Detail
Binding
CHEMBL748108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor
3
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.59 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173031 | — | — | 3 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173031 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL173031 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL173031 | — | IC50 | = | 2393.0 | nM | 5.62 |