Assay Detail

CHEMBL748119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of [125I]-labeled NPY binding to rat hyphalamic membranes

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Subcellular	Membrane
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

[D-TRP32]neuropeptide Y: a competitive antagonist of NPY in rat hypothalamus.

Balasubramaniam A, Sheriff S, Johnson ME, Prabhakaran M, Huang Y, Fischer JE, Chance WT.
J Med Chem (1994) 37 : 811 -815
PubMed 8145232 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.86	9.20

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL267633	NEUROPEPTIDE-Y	—	1	9.20
CHEMBL427782	—	—	1	8.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL267633	NEUROPEPTIDE-Y	IC50	=	0.63	nM	9.20
CHEMBL427782	—	IC50	=	3.0	nM	8.52