Compound Detail
CHEMBL267633
NEUROPEPTIDE-Y Enter ChEMBL ID:
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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC
Basic Information
| ChEMBL ID | CHEMBL267633 |
| Name | NEUROPEPTIDE-Y |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | URPYMXQQVHTUDU-OFGSCBOVSA-N |
6
Targets
21
Activities
3
Assay Types
0
PK Parameters
17
Publications
0
Known Names
Molecular Properties
4253.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 12 meas. best 10.16
Ki 8 meas. best 10.55
Kd 1 meas. best 4.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 CHEMBL4018 | Ki | 10.55 | 10.0533 | 0.0 | 3 |
| Neuropeptide Y receptor type 2 CHEMBL4018 | IC50 | 10.16 | 9.7833 | 0.1 | 3 |
| Unchecked CHEMBL612545 | IC50 | 10.15 | 9.675 | 0.1 | 2 |
| Neuropeptide Y receptor type 1 CHEMBL4777 | Ki | 9.92 | 9.124 | 0.1 | 5 |
| Neuropeptide Y receptor type 1 CHEMBL4777 | IC50 | 9.77 | 9.265 | 0.2 | 4 |
| Rattus norvegicus CHEMBL376 | IC50 | 9.74 | 8.755 | 0.2 | 2 |
| Neuropeptide Y receptor type 2 CHEMBL3309 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| No relevant target CHEMBL2362975 | Kd | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2918505 | 10.1021/jm00123a014 | Rattus norvegicus | 3 |
| 28849908 | 10.1021/acschembio.7b00481 | Neuropeptide Y receptor type 1 | 2 |
| 28849908 | 10.1021/acschembio.7b00481 | Neuropeptide Y receptor type 2 | 2 |
| 19053784 | 10.1021/jm801018u | Neuropeptide Y receptor type 1 | 2 |
| 18983139 | 10.1021/jm8007618 | Neuropeptide Y receptor type 2 | 2 |
| 18983139 | 10.1021/jm8007618 | Neuropeptide Y receptor type 1 | 2 |
| 10978189 | 10.1021/jm000052z | Neuropeptide Y receptor type 2 | 2 |
| 8145232 | 10.1021/jm00032a015 | Rattus norvegicus | 1 |
| 32364733 | 10.1021/acs.jmedchem.0c00027 | Neuropeptide Y receptor type 1 | 1 |
| 8254609 | 10.1021/jm00076a007 | Neuropeptide Y receptor type 2 | 1 |
| 8254609 | 10.1021/jm00076a007 | Neuropeptide Y receptor type 1 | 1 |
| 8145232 | 10.1021/jm00032a015 | Unchecked | 1 |
| 2918505 | 10.1021/jm00123a014 | Unchecked | 1 |
| 1552507 | 10.1021/jm00084a021 | No relevant target | 1 |
| 1552507 | 10.1021/jm00084a021 | Rattus norvegicus | 1 |
| 1552507 | 10.1021/jm00084a021 | Unchecked | 1 |
| 10978189 | 10.1021/jm000052z | Neuropeptide Y receptor type 1 | 1 |
Data from ChEMBL 36 via Core Engine