Assay Detail
Binding
CHEMBL755164
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Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 8.18 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269503 | — | — | 1 | 10.15 |
| CHEMBL267633 | NEUROPEPTIDE-Y | — | 1 | 9.49 |
| CHEMBL441007 | — | — | 1 | 9.41 |
| CHEMBL412698 | — | — | 1 | 9.01 |
| CHEMBL384306 | — | — | 1 | 8.98 |
| CHEMBL410792 | — | — | 1 | 8.96 |
| CHEMBL429905 | — | — | 1 | 8.94 |
| CHEMBL269267 | — | — | 1 | 8.89 |
| CHEMBL412704 | — | — | 1 | 8.88 |
| CHEMBL214707 | — | — | 1 | 8.86 |
| CHEMBL412257 | — | — | 1 | 8.76 |
| CHEMBL413612 | — | — | 1 | 8.74 |
| CHEMBL428320 | — | — | 1 | 8.68 |
| CHEMBL410938 | — | — | 1 | 8.68 |
| CHEMBL430274 | — | — | 1 | 8.58 |
| CHEMBL427594 | — | — | 1 | 8.57 |
| CHEMBL411637 | — | — | 1 | 8.50 |
| CHEMBL411200 | — | — | 1 | 8.43 |
| CHEMBL425095 | — | — | 1 | 8.42 |
| CHEMBL405527 | — | — | 1 | 8.25 |
| CHEMBL429698 | — | — | 1 | 8.15 |
| CHEMBL262221 | — | — | 1 | 8.00 |
| CHEMBL412378 | — | — | 1 | 7.85 |
| CHEMBL406128 | — | — | 1 | 7.39 |
| CHEMBL411800 | — | — | 1 | 7.28 |
| CHEMBL438923 | — | — | 1 | 7.26 |
| CHEMBL2111764 | — | — | 1 | 7.25 |
| CHEMBL266021 | — | — | 1 | 7.24 |
| CHEMBL428292 | — | — | 1 | 7.23 |
| CHEMBL217692 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269503 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL267633 | NEUROPEPTIDE-Y | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL441007 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL412698 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL384306 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL410792 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL429905 | — | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL269267 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL412704 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL214707 | — | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL412257 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL413612 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL428320 | — | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL410938 | — | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL430274 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL427594 | — | IC50 | = | 2.68 | nM | 8.57 |
| CHEMBL411637 | — | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL411200 | — | IC50 | = | 3.73 | nM | 8.43 |
| CHEMBL425095 | — | IC50 | = | 3.84 | nM | 8.42 |
| CHEMBL405527 | — | IC50 | = | 5.61 | nM | 8.25 |
| CHEMBL429698 | — | IC50 | = | 7.08 | nM | 8.15 |
| CHEMBL262221 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL412378 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL406128 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL411800 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL438923 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2111764 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL266021 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL428292 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL217692 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL438935 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL263350 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL438411 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL413232 | — | IC50 | = | 864.0 | nM | 6.06 |
| CHEMBL268409 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL441936 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL438096 | — | IC50 | = | - | nM | - |
| CHEMBL415644 | — | IC50 | > | 100.0 | nM | - |