Compound Detail
CHEMBL428320
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C
Basic Information
| ChEMBL ID | CHEMBL428320 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | XYGISTKWICJNMB-PCIBKGKQSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1954.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 CHEMBL4018 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
| Neuropeptide Y receptor type 2 CHEMBL3309 | IC50 | 8.49 | 8.49 | 3.2 | 1 |
| Neuropeptide Y receptor type 1 CHEMBL4777 | IC50 | 7.11 | 7.11 | 77.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 | IC50 | = | 2.09 | nM | 8.68 | Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line | 10978189 |
| Neuropeptide Y receptor type 2 | IC50 | = | 3.2 | nM | 8.49 | Tested for the affinity for intestinal PYY from rat jejunum by using short circu... | 10978189 |
| Neuropeptide Y receptor type 1 | IC50 | = | 76.95 | nM | 7.11 | Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line | 10978189 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10978189 | 10.1021/jm000052z | Canis familiaris | 6 |
| 10978189 | 10.1021/jm000052z | Neuropeptide Y receptor type 2 | 2 |
| 10978189 | 10.1021/jm000052z | Neuropeptide Y receptor type 1 | 1 |
| 10978189 | 10.1021/jm000052z | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine