Compound Detail
CHEMBL384306
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Basic Information
| ChEMBL ID | CHEMBL384306 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LXGQDTWXFDMBPI-TXCZKBKASA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1940.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 CHEMBL4018 | IC50 | 8.98 | 8.98 | 1.1 | 1 |
| Neuropeptide Y receptor type 2 CHEMBL3309 | IC50 | 8.95 | 8.95 | 1.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 | IC50 | = | 1.05 | nM | 8.98 | Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line | 10978189 |
| Neuropeptide Y receptor type 2 | IC50 | = | 1.12 | nM | 8.95 | Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short... | 10978189 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10978189 | 10.1021/jm000052z | Neuropeptide Y receptor type 2 | 2 |
| 10978189 | 10.1021/jm000052z | Neuropeptide Y receptor type 1 | 1 |
Data from ChEMBL 36 via Core Engine