Assay Detail
Binding
CHEMBL748176
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Compound was tested for the concentration that inhibited the specific binding of (-)-[3H]-NMS to muscarinic acetylcholine receptor in the rat cerebral cortex.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.20 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354685 | — | — | 1 | 6.11 |
| CHEMBL169112 | — | — | 1 | 5.21 |
| CHEMBL354983 | — | — | 1 | 5.19 |
| CHEMBL424383 | — | — | 1 | 4.27 |
| CHEMBL169850 | — | — | 1 | - |
| CHEMBL167892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354685 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL169112 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL354983 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL424383 | — | Ki | = | 53200.0 | nM | 4.27 |
| CHEMBL169850 | — | Ki | = | 145000.0 | nM | - |
| CHEMBL167892 | — | Ki | = | 204000.0 | nM | - |