Assay Detail
Binding
CHEMBL748198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the inhibitory activity by the inhibition of excitatory L-[3H]Glutamate binding to NMDA recognition sites
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Enzymatic asymmetric synthesis of (2R, 4R, 5S)-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid, a potent, selective and competitive NMDA antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.05 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29811 | CGP-37849 | — | 1 | 7.59 |
| CHEMBL47277 | — | — | 1 | 6.49 |
| CHEMBL107660 | — | — | 1 | 6.22 |
| CHEMBL322304 | — | — | 1 | 5.80 |
| CHEMBL108823 | — | — | 1 | 5.59 |
| CHEMBL108096 | — | — | 1 | 5.50 |
| CHEMBL107961 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29811 | CGP-37849 | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL47277 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL107660 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL322304 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL108823 | — | IC50 | = | 2589.0 | nM | 5.59 |
| CHEMBL108096 | — | IC50 | = | 3132.0 | nM | 5.50 |
| CHEMBL107961 | — | IC50 | = | 6458.0 | nM | 5.19 |