Compound Detail
CHEMBL29811
CGP-37849 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL29811 |
| Name | CGP-37849 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BDYHNCZIGYIOGJ-DUXPYHPUSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
209.1
MW (Da)
-0.48
ALogP
3
HBA
4
HBD
120.8
PSA (Ų)
0.37
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.75
Ki 1 meas. best 7.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate [NMDA] receptor CHEMBL2094124 | IC50 | 7.75 | 7.67 | 18.0 | 2 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 7.46 | 7.46 | 35.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 7.46 | 7.46 | 35.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2A CHEMBL310 | IC50 | 7.46 | 7.06 | 35.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate [NMDA] receptor | IC50 | = | 18.0 | nM | 7.75 | Tested for the inhibitory activity by the inhibition of excitatory [3H]CGS-19,75... | - |
| Glutamate [NMDA] receptor | IC50 | = | 25.7 | nM | 7.59 | Tested for the inhibitory activity by the inhibition of excitatory L-[3H]Glutama... | - |
| Glutamate NMDA receptor | IC50 | = | 35.0 | nM | 7.46 | Ability to displace [3H]CPP from NMDA receptor in rat brain membrane | 1533422 |
| Glutamate receptor ionotropic, NMDA 2A | IC50 | = | 35.0 | nM | 7.46 | Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2A | 16107147 |
| Glutamate NMDA receptor | Ki | = | 35.0 | nM | 7.46 | Compound was evaluated for its ability to displace [3H]-CPP ligand from N-methyl... | 1533680 |
| Glutamate receptor ionotropic, NMDA 2A | IC50 | = | 220.0 | nM | 6.66 | Inhibition of [3H]Glu binding to rat N-methyl-D-aspartic acid receptor 2A | 16107147 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80088-8 | Mus musculus | 3 |
| - | 10.1016/S0960-894X(00)80086-4 | Unchecked | 3 |
| 1533680 | 10.1021/jm00087a002 | Glutamate NMDA receptor | 2 |
| - | 10.1016/S0960-894X(00)80086-4 | Glutamate [NMDA] receptor | 2 |
| - | 10.1016/S0960-894X(00)80093-1 | Mus musculus | 2 |
| 16107147 | 10.1021/jm050174x | Glutamate receptor ionotropic, NMDA 2A | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.1016/S0960-894X(00)80087-6 | Rattus norvegicus | 1 |
| - | 10.1016/S0960-894X(00)80087-6 | Rodentia sp. | 1 |
| - | 10.1016/S0960-894X(00)80093-1 | Rattus norvegicus | 1 |
| - | 10.1016/S0960-894X(00)80093-1 | Unchecked | 1 |
| 1533422 | 10.1021/jm00086a004 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine