Assay Detail
Binding
CHEMBL748247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.86 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 7.77 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.89 |
| CHEMBL978 | METHACHOLINE | 4.0 | 1 | 6.42 |
| CHEMBL12587 | MUSCARINE | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL14 | CARBACHOL | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL978 | METHACHOLINE | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL12587 | MUSCARINE | IC50 | = | 449.0 | nM | 6.35 |