Assay Detail
Binding
CHEMBL748248
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Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.78 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 6.92 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.51 |
| CHEMBL12587 | MUSCARINE | — | 1 | 5.41 |
| CHEMBL978 | METHACHOLINE | 4.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL14 | CARBACHOL | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL12587 | MUSCARINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL978 | METHACHOLINE | IC50 | = | 5200.0 | nM | 5.28 |