Assay Detail
Binding
CHEMBL748254
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Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.94 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130835 | PIPERTRAMINE AMIDE | — | 1 | 8.04 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130835 | PIPERTRAMINE AMIDE | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 14.3 | nM | 7.84 |