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Assay Detail

CHEMBL748410

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Receptor binding affinity (Ki) for Muscarinic acetylcholine receptor (urinary bladder) was determined by competition radioligand -[3H]- QNB binding assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Muscarinic acetylcholine receptor (CHEMBL2094109)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.
Nordvall G, Sundquist S, Johansson G, Glas G, Nilvebrant L, Hacksell U.
J Med Chem (1996) 39 : 3269 -3277
PubMed 8765510 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.43 7.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109405 1 7.17
CHEMBL332469 1 7.01
CHEMBL113397 1 6.97
CHEMBL415510 1 6.94
CHEMBL109349 1 6.81
CHEMBL110690 1 6.48
CHEMBL109249 1 6.48
CHEMBL109565 1 6.44
CHEMBL326431 1 6.22
CHEMBL325509 1 6.00
CHEMBL113746 1 5.89
CHEMBL432409 1 5.77
CHEMBL320745 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109405 Ki = 67.0 nM 7.17
CHEMBL332469 Ki = 97.0 nM 7.01
CHEMBL113397 Ki = 107.0 nM 6.97
CHEMBL415510 Ki = 116.0 nM 6.94
CHEMBL109349 Ki = 156.0 nM 6.81
CHEMBL110690 Ki = 330.0 nM 6.48
CHEMBL109249 Ki = 332.0 nM 6.48
CHEMBL109565 Ki = 364.0 nM 6.44
CHEMBL326431 Ki = 600.0 nM 6.22
CHEMBL325509 Ki = 1000.0 nM 6.00
CHEMBL113746 Ki = 1300.0 nM 5.89
CHEMBL432409 Ki = 1700.0 nM 5.77
CHEMBL320745 Ki = 3900.0 nM 5.41